Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Kristina Ellwanger0
Michael Tesar0
Martin Treder0
Uwe Reusch0
Thorsten Ross0
Erich Rajkovic0
Ivica Fucek0
Joachim Koch0
Date of Patent
May 11, 2021
Patent Application Number
16714396
Date Filed
December 13, 2019
Patent Primary Examiner
Patent abstract
The invention relates to multispecific antigen-binding proteins for engaging natural killer (NK) cells for triggering NK cell cytotoxicity by engaging the CD16A (FcγRIIIA) expressed on NK cells, wherein the antigen-binding protein comprises at least two CD16A antigen-binding moieties and at least a further target antigen-binding moiety. The CD16A antigen-binding moiety comprises light chain and heavy chain variable regions linked one after another in a polypeptide chain and the variable region at the N-terminus of the polypeptide chain comprising the CD16A antigen-binding moiety is a light chain variable region.
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