Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Reena Varkey0
Xiaodong Xiao0
David Tice0
Elaine M. Hurt0
Krista Kinneer0
Date of Patent
April 27, 2021
Patent Application Number
16050944
Date Filed
July 31, 2018
Patent Citations Received
Patent Primary Examiner
Patent abstract
The disclosure is directed to an antibody-drug conjugate (ADC) comprising a monoclonal antibody, or an antigen-binding fragment thereof, directed against B-cell maturation antigen (BCMA) conjugated to a cytotoxin. The disclosure also provides compositions comprising the antibody-drug conjugate and methods of killing multiple myeloma cells (including multiple myeloma stems cells) that express BCMA by contacting multiple myeloma cells with the ADC.
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