In some aspects, a quantum simulation method includes generating a set of models representing a quantum system. The set of models includes subsystem models representing respective fragments of the quantum system. The quantum system is simulated by operating the set of models on a computer system that includes a classical processor unit and multiple unentangled quantum processor units (QPUs), and the unentangled QPUs operate the respective subsystem models. In some examples, density matrix embedding theory (DMET) is used to compute an approximate ground state energy for the quantum system.