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US Patent 10982288 Methods of detecting MLH1 methylation

Patent 10982288 was granted and assigned to Quest Diagnostics on April, 2021 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Patent Applicant
Quest Diagnostics
Quest Diagnostics
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Current Assignee
Quest Diagnostics
Quest Diagnostics
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
109822880
Patent Inventor Names
Kevin Qu0
Amber Donahue0
Feras Hantash0
Date of Patent
April 20, 2021
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Patent Application Number
163243650
Date Filed
August 9, 2017
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Patent Primary Examiner
‌
Amanda Haney
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Patent abstract

The present technology relates to methods for excluding Lynch syndrome as a possible diagnosis in patients suffering from colorectal cancers or endometrial cancers. These methods are based on detecting the methylation status of the MLH1 promoter ‘C’ region in colorectal and endometrial cancer patients using an improved and highly sensitive methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay.

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