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US Patent 10927346 Enhanced immune effector cells and use thereof

Patent 10927346 was granted and assigned to Fate Therapeutics Inc on February, 2021 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
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Current Assignee
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
109273460
Patent Inventor Names
Bahram Valamehr0
Jode Goodridge0
Ryan Bjordahl0
Tom Tong Lee0
Date of Patent
February 23, 2021
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Patent Application Number
165764110
Date Filed
September 19, 2019
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Patent Citations Received
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US Patent 12122846 Chimeric antigen receptor for tumor targeting
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US Patent 11591381 Gene-edited natural killer cells
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US Patent 11661459 Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
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US Patent 11365394 Enhanced immune effector cells and use thereof
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US Patent 11883432 Chimeric antigen receptor system with adaptable receptor specificity
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US Patent 12104178 DHFR tunable protein regulation
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US Patent 11459372 Gene-edited natural killer cells
Patent Primary Examiner
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Marcia S Noble
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Patent abstract

Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs. The derivative cells provided herein have stable and functional genome editing that delivers improved or enhanced therapeutic effects. Also provided are therapeutic compositions and the used thereof comprising the functionally enhanced derivative effector cells alone, or with antibodies or checkpoint inhibitors in combination therapies.

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