Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
February 16, 2021
Patent Application Number
16162747
Date Filed
October 17, 2018
Patent Citations
Patent Citations Received
0
Patent Primary Examiner
Patent abstract
The present invention provides a chimeric antigen receptor (CAR) comprising; (i) a B cell maturation antigen (BCMA)-binding domain which comprises at least part of a proliferation-inducing ligand (APRIL); (ii) a spacer domain (iii) a transmembrane domain; and (iv) an intracellular T cell signaling domain. The invention also provides the use of such a T-cell expressing such a CAR in the treatment of plasma-cell mediated diseases, such as multiple myeloma.
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