US Patent 10918884 Fluence map generation methods for radiotherapy

Described herein are methods for fluence map generation or fluence map optimization (FMO) for radiation therapy. One variation of a method for generating a fluence map comprises smoothing out nondifferentiable penalty functions and using an accelerated proximal gradient method (e.g., FISTA) to compute a fluence map that may be used by a radiotherapy system to apply a selected dose of radiation to one or more regions of interest (ROI) or volumes of interest (VOI).