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US Patent 10905739 Peptidomimetic macrocycles and formulations thereof

Patent 10905739 was granted and assigned to Aileron Therapeutics on February, 2021 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

Aileron Therapeutics

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Current Assignee

Aileron Therapeutics

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Sonoko Kanai0

Joerg Hoernschemeyer0

Krzysztof Darlak0

Michaela Grass0

Chris Rhodes0

David Allen Annis0

Date of Patent

February 2, 2021

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Patent Application Number

148646870

Date Filed

September 24, 2015

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Patent Citations

US Patent 10030049 Triazole macrocycle systems

US Patent 10022422 Peptidomimetic macrocycles

US Patent 10023613 Peptidomimetic macrocycles as modulators of MCL-1

US Patent 10059741 Peptidomimetic macrocycles

Patent Primary Examiner

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Patent abstract

Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed. Also disclosed are methods of treating diseases and disorders using the aqueous pharmaceutical formulations disclosed herein.

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