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US Patent 10898584 Modified RNA with decreased immunostimulatory properties

Patent 10898584 was granted and assigned to CureVac on January, 2021 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

Current Assignee

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

Date of Patent

January 26, 2021

Patent Application Number

15142082

Date Filed

April 29, 2016

Patent Citations Received

US Patent 12109275 Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded protein

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US Patent 11865084 MERS coronavirus vaccine

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US Patent 11965000 Respiratory syncytial virus (RSV) vaccine

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US Patent 12083190 Rabies vaccine

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US Patent 11661634 Method for producing RNA

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US Patent 11667910 Method for producing and purifying RNA, comprising at least one step of tangential flow filtration

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US Patent 11760992 Method for producing and purifying RNA, comprising at least one step of tangential flow filtration

US Patent 11761009 Artificial nucleic acid molecules for improved protein expression

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Patent Primary Examiner

Patent abstract

The present invention provides a method for providing modified mRNAs of reduced immunogenicity and/or immunostimulatory capacity for use in protein replacement therapy. The invention further provides modified mRNAs and pharmaceutical compositions comprising the modified mRNAs according to the invention for use in protein replacement therapy.

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