Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Michael C. Jensen0
Andrew Scharenberg0
David Rawlings0
Kamila Gwiazda0
Alexandra Grier0
Date of Patent
February 18, 2020
0Patent Application Number
151529600
Date Filed
May 12, 2016
0Patent Primary Examiner
Patent abstract
Disclosed herein are nuclease-based systems for genome editing and methods of using the system for genome editing. Also, disclosed are approaches to enhance Cas9-mediated gene editing efficiency in primary human cells with minimal toxicity when using adeno-associated virus vectors (AAV) to express the guide RNAs necessary for CRISPR/Cas9-based genome editing in the presence of helper proteins.
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