Is a
Patent attributes
Patent Applicant
0
Current Assignee
0
Patent Jurisdiction
Patent Number
Patent Inventor Names
Gregory Walter Hiller0
Bhanu Chandra Mulukutla0
Date of Patent
January 28, 2020
0Patent Application Number
151264890
Date Filed
March 17, 2015
0Patent Citations Received
Patent Primary Examiner
Patent abstract
A method of cell culture comprising providing cells in a cell culture medium to start a cell culture process, and,maintaining at least one metabolite selected from 3-(4-hydroxyphenyl)lactate, 4-hydroxyphenylpyruvate, phenyllactate, indolelactate, indolecarboxylic acid, homocysteine, 2-hydroxybutyric acid, isovalerate and formate below a concentration C1 in the cell culture medium, wherein C1 is 3 mM and/or(ii) maintaining at least one amino acid selected from phenylalanine, tyrosine, tryptophan, methionine, leucine, serine, threonine and glycine below a concentration C2 in the cell culture medium, wherein C2 is 2 mM.
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