Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Wenjun Zhang0
Date of Patent
January 21, 2020
Patent Application Number
15542781
Date Filed
August 3, 2016
Patent Citations Received
Patent Primary Examiner
Patent abstract
Novel multispecific antibody platform, multispecific antibodies and a method to make the antibodies is disclosed here. The CH3 domain harboring polypeptide chains of the Fc-regions are modified by increasing the positive charge of one chain and negative charge of another chain. Heterodimer formation in cotransfection with the modified chains is comparable to formation of wild type antibodies when same cell line is transfected with wild type polypeptides. Moreover, the modification provides a simple one step purification of the heterodimers.
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