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US Patent 10519249 Covalently linked polypeptide toxin-antibody conjugates

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Is a
Patent
Patent

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
10519249
Date of Patent
December 31, 2019
Patent Application Number
15200629
Date Filed
July 1, 2016
Patent Citations Received
‌
US Patent 12023378 Covalently linked antigen-antibody conjugates
3
‌
US Patent 11673968 Anti-BRDU antibodies and methods of use
4
Patent Primary Examiner
‌
Stephen L. Rawlings
Patent abstract

Herein is reported a conjugate of a haptenylated polypeptide toxin and an anti-hapten antibody, wherein a disulfide bond is formed between a cysteine residue either before or after the lysine residue that is used for hapten-conjugation and a cysteine residue in the CDR2 of the antibody, whereby the CDR2 is determined according to Kabat.

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