A one-piece-vamp manufacture method includes: (1) weaving preparation: arranging different required raw material color yarn, hot melt silk and stretch yarn at a main color opening yarn feeding orifice, a match color opening yarn feeding orifice and a stretch yarn yarn feeding orifice; (2) weaving U shape tube fabric: a vamp machine weaving in an order of a starting opening, an outer toe cap, an outer shoe body, an outer heel, an outer shoe opening to an inner shoe opening, an inner heel, an inner shoe body, an inner toe cap; (3) stitching an inner toe cap stitch eyelet; (4) stitching the outer toe cap stitch eyelet; (5) forming a one-piece-vamp semifinished product; and (6) reshaping, setting and shape fixing.