An information management system according to certain aspects uses backup copies or other secondary copies of production data for the purposes of replicating production data to another client. The secondary copies can be deduplicated copies. By utilizing available secondary copies of the data for replication, the system can reduce the impact on the production machines associated with replication. Utilizing deduplicated copies not only reduces the amount of stored data, but also reduces the amount of data that is communicated between the source and the destination, increasing the speed of the replication process.