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US Patent 10457980 Multiplex labeling of molecules by sequential hybridization barcoding

Patent 10457980 was granted and assigned to California Institute of Technology on October, 2019 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

California Institute of Technology

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Current Assignee

California Institute of Technology

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Sheel Shah1

Chang Ho Sohn1

Eric Lubeck1

Long Cai1

Timur Zhiyentayev1

Ting-Fang He1

Ahmet Coskun1

Date of Patent

October 29, 2019

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Patent Application Number

144357351

Date Filed

April 30, 2014

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Patent Citations Received

US Patent 12116626 AP50 polymerases and uses thereof

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US Patent 11359228 Methods and systems for determining spatial patterns of biological targets in a sample

US Patent 11390912 Spatially distinguished, multiplex nucleic acid analysis of biological specimens

US Patent 11959075 Systems and methods for determining nucleic acids

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US Patent 11976318 Compositions and methods for analyte detection

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US Patent 12060603 Methods for internally controlled in situ assays using padlock probes

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US Patent 12071667 Sequence analysis using meta-stable nucleic acid molecules

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Patent Primary Examiner

Ethan C. Whisenant

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Patent abstract

The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. In some embodiments, through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci.

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