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US Patent 10428153 Human anti TSHR antibodies

Patent 10428153 was granted and assigned to RSR on October, 2019 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Patent Applicant
‌
RSR
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Current Assignee
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RSR
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
104281530
Patent Inventor Names
Jane Sanders0
Bernard Rees-Smith0
Jadwiga Furmaniak0
Date of Patent
October 1, 2019
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Patent Application Number
147904890
Date Filed
July 2, 2015
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Patent Primary Examiner
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Stephen Rawlings
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Patent abstract

According to one aspect there is provided An isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on TSHR constitutive activity wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR.

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