Methods and apparatus are disclosed for contamination prevention of vehicle cameras and sensors. An example vehicle includes an exterior, a camera along the exterior and including a lens, and a controller. The controller is to determine, based upon images captured by the camera, whether a contaminant is approaching the lens and identify a contaminant state upon determining the contaminant is approaching the lens. The example vehicle also includes a nozzle to spray washer fluid to prevent contamination of the lens responsive to the controller identifying that the contaminant is a liquid.