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US Patent 10407435 Diheteroaryl histone deacetylase inhibitors and their use in therapy

Patent 10407435 was granted and assigned to Karus Therapeutics on September, 2019 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Karus Therapeutics
Karus Therapeutics
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Current Assignee
Karus Therapeutics
Karus Therapeutics
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
104074350
Patent Inventor Names
Cyrille Davy Tomassi0
Somhairle MacCormick0
Stephen Joseph Shuttleworth0
William John Nodes0
Alexander Richard Liam Cecil0
Date of Patent
September 10, 2019
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Patent Application Number
155221880
Date Filed
October 29, 2015
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Patent Citations
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US Patent 10150763 Histone deacetylase inhibitors and their use in therapy
Patent Citations Received
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US Patent 11858880 Anti-fungals compounds targeting the synthesis of fungal sphingolipids
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US Patent 10870624 Histone deacetylase inhibitors
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US Patent 11390580 Anti-fungals targeting the synthesis of fungal shingolipids
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US Patent 11414378 Anti-fungals compounds targeting the synthesis of fungal sphingolipids
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US Patent 11850233 Reduced adaptive microbial resistance treatment for flesh eating disease (necrotizing fasciitis)
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Patent Primary Examiner
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Jeffrey H Murray
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Patent abstract

The present invention is a compound having the following formula: (Formula (I)) or a pharmaceutically acceptable salt thereof, wherein e.g. X is C or N; n is 1 to 10; each L is independently a 5- to 12-membered heteroaryl containing at least two nitrogen atoms; and W is a zinc-binding group. The compounds are useful as histone deacetylase (HDAC) inhibitors.

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