A fall protection device includes a frame, a rotation unit, a safety belt, a braking plate, a braking block and a restoring spring. The frame includes a first lateral plate, and a stopping block is formed on an exterior surface of the first lateral plate. The rotation unit is rotatably disposed with the frame. The safety belt is wound around the rotation unit. The braking plate is engaged with the rotation unit and includes an interior surface which faces the exterior surface of the first lateral plate. The braking block is pivotally disposed on the braking plate and located between the interior surface of the braking plate and the exterior surface of the first lateral plate. The present invention could ensure the braking block to abut against the stopping block as the braking block is at an expanding position, and thereby to improve a reliability of the lockup function.