A weapon motion alert system includes a weapon that may be manipulated. A base unit is provided and the base unit is removably coupled to the weapon. Additionally, the base unit detects motion. A remote unit is provided and the remote unit is positioned on a support surface. The remote unit is in electrical communication with the base unit. The remote unit generates an alarm sequence when the base unit has been moved. In this way the remote unit alerts a user that the weapon has been tampered with.