Oral hygiene systems and methods for their use are provided. An oral hygiene system includes a mouthpiece having an outer portion and an inner portion configured to receive at least a portion of a user's dental and gum structures, a plurality of filaments disposed within the inner portion of the mouthpiece, a water pressure irrigator configured to be selectively coupled to the outer portion of the mouthpiece and to deliver fluid to the inner portion of the mouthpiece, and a fluid reservoir in fluid communication with the water pressure irrigator and configured to deliver the fluid thereto, wherein the system is configured to generate ultrasound/ultrasonic vibration within the inner portion of the mouthpiece.