Patent 10316002 was granted and assigned to Dana-Farber Cancer Institute on June, 2019 by the United States Patent and Trademark Office.
The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of EGFR, FGFR, ALK, ROS, JAK, BTK, BLK, ITK, TEC, and/or TXK and their use for the treatment of cell proliferation disorders are described.