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US Patent 10294518 Methods and systems for ultra-sensitive detection of genomic alterations

Patent 10294518 was granted and assigned to Fluxion Biosciences on May, 2019 by the United States Patent and Trademark Office.

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Patent
Patent

Patent attributes

Patent Applicant
Fluxion Biosciences
Fluxion Biosciences
Current Assignee
Fluxion Biosciences
Fluxion Biosciences
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
10294518
Patent Inventor Names
Nicholas Kamps-Hughes1
Cristian Ionescu-Zanetti1
Date of Patent
May 21, 2019
Patent Application Number
15268349
Date Filed
September 16, 2016
Patent Primary Examiner
‌
John S. Brusca
Patent abstract

The invention discloses methods and apparatuses for the detection and diagnostics of genetic alterations/mutations in a target sample, which may be a solid tissue or a bodily fluid. A reference sample is also acquired, and the target and reference samples are replicated into multiple target and reference replicates. The replicates are sequenced, and the sequence data is analyzed based on a statistical test. The statistical test compares the measurements between the target and reference replicates at respective allelic indices. True positive calls are then made based on the results of the statistical testing, and the desired genetic alterations/mutations are identified at the base-pair level. The invention may be used for diagnostics related to cancer, auto-immune disease, organ transplant rejection, genetic fetal abnormalities and pathogens.

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