Disclosed herein is a high-intensity focused ultrasound operation device including a handle part for manipulation by an operator, an insertion part provided at the front end of the handle part and inserted into a vagina during operation, an ultrasound treatment transducer provided to the insertion part to generate high-intensity focused ultrasound, a driver for driving the ultrasound treatment transducer, and a controller for controlling the driver. The high-intensity focused ultrasound operation device may be utilized for a variety of operations such as beauty treatment, adipolysis, gynecological disease treatment, etc.