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US Patent 10272178 Methods for blood-brain barrier disruption using electrical energy

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Contents

Is a
Patent
Patent

Patent attributes

Patent Applicant
Virginia Tech Intellectual Properties
Virginia Tech Intellectual Properties
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
10272178
Date of Patent
April 30, 2019
Patent Application Number
15424335
Date Filed
February 3, 2017
Patent Citations Received
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US Patent 12102376 System and method for increasing a target zone for electrical ablation
0
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US Patent 11952568 Device and methods for delivery of biphasic electrical pulses for non-thermal ablation
0
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US Patent 11974800 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
0
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US Patent 12059197 Blood-brain barrier disruption using reversible or irreversible electroporation
0
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US Patent 10448989 High-frequency electroporation for cancer therapy
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US Patent 10470822 System and method for estimating a treatment volume for administering electrical-energy based therapies
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US Patent 10471254 Selective modulation of intracellular effects of cells using pulsed electric fields
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US Patent 10537379 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
...
Patent Primary Examiner
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Taeyoon Kim
Patent abstract

The present invention provides engineered tissue scaffolds, engineered tissues, and methods of using them. The scaffolds and tissues are derived from natural tissues and are created using non-thermal irreversible electroporation (IRE). Use of IRE allows for ablation of cells of the tissue to be treated, but allows vascular and neural structures to remain essentially unharmed. Use of IRE thus permits preparation of thick tissue scaffolds and tissues due to the presence of vasculature within the scaffolds. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.

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