Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Phillip B. Maples0
Donald Rao0
John J. Nemunaitis0
Neil Senzer0
Date of Patent
April 9, 2019
0Patent Application Number
156900920
Date Filed
August 29, 2017
0Patent Primary Examiner
Patent abstract
Compositions and methods for cancer treatment are disclosed herein. More specifically, the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.
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