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US Patent 10167266 Sodium channel blockers

Patent 10167266 was granted and assigned to Parion Sciences on January, 2019 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

Parion Sciences

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Current Assignee

Parion Sciences

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Michael R. Johnson0

Date of Patent

January 1, 2019

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Patent Application Number

153365740

Date Filed

October 27, 2016

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Patent Citations Received

US Patent 10752597 3,5-diamino-6-chloro-N—(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide

US Patent 11578042 3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide

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Patent Primary Examiner

Jeffrey H Murray

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Patent abstract

The present invention relates to compounds of Formula (I) and pharmaceutical compositions thereof. Compounds of Formula (I) are epithelial sodium channel (ENaC) blockers useful in the hydration of mucosal surfaces, enhancement of mucociliary clearance, or restoration of mucosal defense in a subject. The compounds and compositions can therefore be used to treat diseases which rely on the hydration of mucosal surfaces.

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