US Patent 10155785 Methods for purification of messenger RNA
Patent 10155785 was granted and assigned to Translate Bio on December, 2018 by the United States Patent and Trademark Office.
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The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of (a) precipitating mRNA from an impure preparation; (b) subjecting the impure preparation comprising precipitated mRNA to a purification process involving membrane filtration such that the precipitated mRNA is captured by a membrane; and (c) eluting the captured precipitated mRNA from the membrane by re-solubilizing the mRNA, thereby resulting in a purified mRNA solution. In some embodiments, a purification process involving membrane filtration suitable for the present invention is tangential flow filtration.
US Patent 10155785 Methods for purification of messenger RNA
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