Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Carl H. June0
Daniel J. Powell, Jr.0
Date of Patent
November 6, 2018
Patent Application Number
14044569
Date Filed
October 2, 2013
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides compositions and methods for inducing a CAR mediated trans-signal in a T cell. The trans-signaling CAR T cells comprise a first CAR having a first signaling module and a second CAR having a distinct second signaling module. The present invention also provides cells comprising a plurality of types of CARs, wherein the plurality of types of CARs participate in trans-signaling to induce T cell activation.
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