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US Patent 10005846 Anti-transglutaminase 2 antibodies

Patent 10005846 was granted and assigned to LifeArc on June, 2018 by the United States Patent and Trademark Office.

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Patent
Patent

Patent attributes

Patent Applicant
‌
Medical Research Council Technology
Current Assignee
LifeArc
LifeArc
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
10005846
Date of Patent
June 26, 2018
Patent Application Number
14402675
Date Filed
May 24, 2013
Patent Primary Examiner
‌
Lei Yao
Patent abstract

The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.

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