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US Patent 10000740 In vitro production of foregut stem cells

Patent 10000740 was granted and assigned to Cambridge Enterprise on June, 2018 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Cambridge Enterprise
Cambridge Enterprise
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Current Assignee
Cambridge Enterprise
Cambridge Enterprise
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
100007400
Patent Inventor Names
Nicholas Hannan0
Ludovic Vallier0
Date of Patent
June 19, 2018
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Patent Application Number
150280850
Date Filed
October 6, 2014
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Patent Citations Received
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US Patent 11584916 Method of making in vivo human small intestine organoids from pluripotent stem cells
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US Patent 11767515 Colonic organoids and methods of making and using same
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US Patent 11066650 Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
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US Patent 11053477 Methods and systems for converting precursor cells into gastric tissues through directed differentiation
Patent Primary Examiner
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Kevin K Hill
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Patent abstract

This invention relates to the differentiation of pluripotent cells (PSCs) into foregut stem cells (FSCs) using a definitive endoderm induction medium comprising a TGFfi ligand, fibroblast growth factor (FGF), bone morphogenetic protein (BMP) and a PI3K inhibitor to differentiate the pluripotent cells into definitive endoderm cells and a foregut induction medium comprising a TGFβ ligand to differentiate the definitive endoderm cells into foregut stem cells (FSCs). Methods of differentiation, populations of foregut stem cells, culture media and kits are provided.

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