BACKGROUND: Recent evidences showed that the phytoestrogen genistein positively affects bone metabolism with no clinically significant adverse effects in a cohort of osteopenic, postmenopausal women. However, there is still a knowledge gap regarding the long-term safety of genistein on the breast, the uterus, the thyroid gland and its efficacy in postmenopausal women. OBJECTIVE: To assess the safety profile of genistein on mammary and thyroid glands and endometrium and cardiovascular apparatus and its effects on bone metabolism after a 3-year therapy with pure, standardized genistein (54 mg/day).

Infobox

Is a

‌

Clinical study

NCT Number

NCT006267690

Trial Recruitment Size

1380

Trial Sponsor

University of Messina

Clinical Trial Start Date

2005

Primary Completion Date

2006

Study Completion Date

2006

Clinical Trial Study Type

Observational0

Observational Clinical Trial Type

Cohort0

Observational Study Perspective

Prospective0

Official Website

https://clinicaltrials.gov/study/NCT006267690

Official Name

Safety Profile and Bone Efficacy of the Phytoestrogen Genistein in a Cohort of Osteopenic, Postmenopausal Women After Three Years of Treatment: a Follow-up Study0

Last Updated

May 19, 2009

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