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Shotgun sequencing

Shotgun sequencing

Shotgun sequencing involves randomly breaking up DNA sequences into lots of small pieces and then reassembling the sequence by looking for regions of overlap.

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Edits on 2 Nov, 2018
Carla Faraguna
Carla Faraguna edited on 2 Nov, 2018
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Shotgun sequencing

Shotgun sequencing involves randomly breaking up DNA sequences into lots of small pieces and then reassembling the sequence by looking for regions of overlap.

Carla Faraguna
Carla Faraguna edited on 2 Nov, 2018
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Shotgun sequencing

Shotgun sequencing involves randomly breaking up DNA sequences into lots of small pieces and then reassembling the sequence by looking for regions of overlap.

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Large, mammalian genomes are particularly difficult to clone, sequence and assemble because of their size and structural complexity. As a result clone-by-clone sequencing, although reliable and methodical, takes a very long time. With the emergence of cheaper sequencing and more sophisticated computer programs, researchers have therefore relied on whole genome shotgun sequencing to tackle larger, more complex genomes.

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Edits on 1 Jan, 2017
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 Shotgun sequencing

Shotgun sequencing involves randomly breaking up DNA sequences into lots of small pieces and then reassembling the sequence by looking for regions of overlap.

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