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Remifentanil Effect on Burst Suppression Ratio

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Contents

clinicaltrials.gov/study/NCT06237101
Is a
‌
Clinical study
0

Clinical Study attributes

NCT Number
NCT062371010
Health Conditions in Trial
Electroencephalography
Electroencephalography
0
Burst suppression
Burst suppression
0
Trial Recruitment Size
200
Trial Sponsor
University of Chile
University of Chile
0
Clinical Trial Start Date
January 22, 2024
0
Primary Completion Date
August 31, 2024
0
Study Completion Date
December 31, 2024
0
Clinical Trial Study Type
Interventional0
Interventional Trial Purpose
Basic Science0
Intervention Type
Drug0
Interventional Trial Phase
Not Applicable0
Official Name
Influence of Variable Plasma Concentrations of Remifentanil on Burst Suppression (BS) Event Rate in Electroencephalographic (EEG) Recordings of Human Subjects Undergoing Total Intravenous General Anesthesia (TIVA) Under Propofol0
Last Updated
February 1, 2024
0
Allocation Type
Randomized0
Intervention Model
Crossover Assignment0
Masking Type
Single0
Masked Party
Participant0

Other attributes

Intervention Treatment
High dose of remifentanil0
Medium dose of remifentanil0
Study summary

The goal of this clinical trial is to determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol in adult patients (18-60 years) candidates for elective surgery who require remifentanil and ASA classification I or II (American Society of Anesthesiology). The main question it aims to answer are: • To determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol. Participants will undergo general anesthesia with remifentanil and propofol sequentially. After loss of consciousness, remifentanil will be adjusted to a medium or high concentration randomly and it will be determined at what concentration of propofol the burst suppressions are generated.. Then, the concentrations of propofol that generate burts suppression associated with either a medium or high concentration of remifentanil will be compared.

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