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Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO)

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clinicaltrials.gov/study/NCT03313817
Is a
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Clinical study
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Clinical Study attributes

NCT Number
NCT033138170
Health Conditions in Trial
Diagnosis
Diagnosis
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Prognosis
0
Magnetic resonance imaging
Magnetic resonance imaging
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Etiology
0
Trial Recruitment Size
900
Trial Sponsor
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Fondation Ophtalmologique Adolphe De Rothschild
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Clinical Trial Start Date
December 13, 2017
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Primary Completion Date
2024
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Study Completion Date
2024
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Clinical Trial Study Type
Observational0
Observational Clinical Trial Type
Case-Only0
Observational Study Perspective
Prospective0
Official Name
Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO)0
Last Updated
July 11, 2023
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Study summary

Central retinal artery occlusions (CRAO) are the equivalent of an ischemic stroke at the retinal level. They share the same risk factors and common pathology. The diagnosis of a CRAO is clinically based on the sudden occurrence of a decrease in deep visual acuity with fundamentally signs of reactive ischemia. Small studies have highlighted the value of cerebral MRI (Magnetic Resonance Imaging) in CRAO with almost 25% of ischemic strokes found on diffusion sequences and the demonstration of a correlation between anomalies in diffusion sequence and the probability of a pathology with a high risk of recurrence (carotid stenosis or emboligenic cardiopathy). But there are usually few radiological signs that allow a direct positive diagnosis of CRAO, an etiologic diagnosis or a prognosis. This descriptive study will focus on CRAO at the diagnostic and post-treatment phases in the short and medium term, in order to (i) identify imaging etiologic signs of CRAO with specific sequences from a 3 Tesla MRI, (ii) identify positive diagnostic signs of CRAO with the same specific sequences, (iii) correlate these signs with the visual prognosis one month after the CRAO.

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