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Modeling Tic Change During Behavior Therapy for Tics

OverviewStructured DataIssuesContributors

Contents

Study summaryTimelineTable: Further ResourcesReferences
clinicaltrials.gov/study/NCT06270251
Is a
‌
Clinical study
1

Clinical Study attributes

NCT Number
NCT062702511
Trial Recruitment Size
301
Trial Sponsor
University of Minnesota
University of Minnesota
1
Clinical Trial Start Date
March 1, 2024
1
Primary Completion Date
March 1, 2028
1
Study Completion Date
September 1, 2028
1
Clinical Trial Study Type
Interventional1
Interventional Trial Purpose
Treatment1
Intervention Type
Behavioral1
Interventional Trial Phase
Not Applicable1
Official Name
Modeling Tic Change During Behavior Therapy for Tics1
Last Updated
February 21, 2024
1
Allocation Type
NA1
Intervention Model
Single Group Assignment1
Masking Type
None (Open Label)1

Other attributes

Intervention Treatment
CBIT1
Study summary

Chronic tics are a disabling neuropsychiatric symptom associated with multiple child-onset mental disorders. Chronic tics affect 1-3% of youth and can be associated with impaired functioning, emotional and behavioral problems, physical pain, diminished quality of life, and peer victimization. Chronic tics are the primary symptom of Tourette Syndrome (TS) and Persistent Motor/Vocal Tic Disorders. CBIT is a manualized treatment focused on increasing tic controllability. Its core procedure is competing response training (CRT), in which patients learn to inhibit tics by learning and applying a competing motor action to one tic at a time. CBIT is recommended as a first-line treatment relative to medications and other therapies. However, only 52% of children and 38% of adults show clinically meaningful tic improvement. Large randomized trials have demonstrated the superiority of CBIT over supportive therapy in child and adult patients, and meta-analysis shows comparable effect sizes for CBIT and medication. Although increasing tic controllability is the primary goal of CBIT, tic controllability nor its correlates have been examined longitudinally during the intervention. The overall objective of this study is to use fine-grained data collection strategies to identify patterns in tic controllability and other relevant related variables that are associated with treatment response to CBIT. Participants with chronic tics will complete a manualized course of 8-session CBIT. Behavioral, psychosocial, and global functioning will be assessed longitudinally to examine predictors and correlates of response. CBIT sessions will be video recorded.

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Further Resources

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