Maven Biotechnology is a California based biotechnology company which develops real-time and label-free imaging technology for protein microarrays, cell-based assays, and multiplex biomarker detection for microplates and disposable slides. The diagnostic technology can include quantitative or qualitative determination of hormones, drugs, metabolic products, tumor markers, autoimmune auto-antibodies, vitamins, and disease agents in biological fluids.
Label Free Internal Reflection Ellipsometry or LFIRE is a real-time polarimetric imaging technology which uses a beam of polarized light directed from the underside of a piece of glass at a specific “critical” angle which is then reflected by the glass-water interface. The reflection produces an electromagnetic wave that responds to the refractive index in the water. A camera with a 12 bit-sensor is used to capture and measure the reflected light beam in real time. The polarization of the reflected beam changes in real time with respect to what the light beam comes in contact with at the interface, which changes its refractive index. This change in polarization allows it to detect small molecules, protein or even cells.
The company’s initial target is immunoassays including various antigen-antibody and kinetic analysis, HCG (Human Chorionic Gonadotropin), species-specific and isotype-specific industrial secondary antibodies. The system can also target autoimmune antigens and infectious disease antigens.