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Hypolipemic Treatment in Acute Coronary Syndrome (ACS): Antithrombotic Effects

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clinicaltrials.gov/study/NCT00725829
Is a
‌
Clinical study
0

Clinical Study attributes

NCT Number
NCT007258290
Health Conditions in Trial
Acute coronary syndrome
Acute coronary syndrome
0
Trial Recruitment Size
1000
Trial Sponsor
Jagiellonian University
Jagiellonian University
0
Clinical Trial Start Date
2008
0
Primary Completion Date
2009
0
Study Completion Date
2009
0
Clinical Trial Study Type
Interventional0
Interventional Trial Purpose
Basic Science0
Intervention Type
Drug0
Interventional Trial Phase
Not Applicable0
Official Name
Effects of Simvastatin Versus Simvastatin Combined With Ezetimibe on Blood Coagulation in Patients With Acute Coronary Events: Relationship With Cholesterol-Lowering and Anti-Inflammatory Properties0
Last Updated
February 10, 2009
0
Allocation Type
Randomized0
Intervention Model
Parallel Assignment0
Masking Type
Quadruple0
Masked Party
Care Provider0
Outcomes Assessor0
Participant0
Investigator0

Other attributes

Intervention Treatment
simvastatin0
placebo0
ezetimibe0
Study summary

The aim of the current study is to evaluate whether treatment with high doses of simvastatin can reduce coagulation activation in patients with acute coronary syndromes and if ezetimibe in conjunction with simvastatin may affect blood clotting in a similar manner. The investigators hypotheses are as follows: 1. Intensive lipid lowering treatment with simvastatin (40 mg/day) and simvastatin (40 mg/day) combined with ezetimibe (10 mg/day) initiated after acute coronary syndrome leads to attenuation of blood coagulation including reduced thrombin generation, thrombin-mediated coagulant reactions, and improved structure of plasma clots. 2. Anticoagulant effects of simvastatin are weaker than those observed during administration of simvastatin and ezetimibe.

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