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Fudan University

Fudan University

An institute of higher education. It was founded in 1905 and is located in Shanghai, China.

Fudan University is a Shanghai-based educational institute that offers both undergraduate and graduate programs as well as doctoral degree programs to its students. It also has affiliated hospitals and researchers.

COVID-19

The university partnered with several other entities, such as Shanghai JiaoTong University and RNACure Biopharma, to develop a vaccine for COVID-19. The partnership revolved around using RNA to develop a lipid nanoparticles-encapsulated mRNA cocktail encoding receptor binding domain.

Timeline

People

Name
Role
LinkedIn

Xu Ningsheng

President

Further reading

Title
Author
Link
Type
Date

CanSino Biological, Moderna, and INOVIO Lead COVID-19 Vaccine Race; 42 Other Candidates in Pre-Clinical Stage

Web

April 10, 2020

Towards an effective mRNA vaccine against 2019-nCoV

Web

Documentaries, videos and podcasts

Title
Date
Link

Shanghai Fudan University

June 25, 2012

Companies

Company
CEO
Location
Products/Services

News

Title
Author
Date
Publisher
Description
August 26, 2021
The Economic Times
As with Western platforms such as Twitter and Facebook, Chinese social media is very much polarized, but the nationalists are increasingly gaining the upper hand. This Chinese take on cancel culture has been fueled by growing national pride -- showcased this year as the Communist Party celebrates its centennial.
Bloomberg
August 26, 2021
@bsindia
Among their targets are celebrities, scientists, feminists and public figures, who can suffer censorship, blacklisting or loss of income
June 9, 2021
AP NEWS
BEIJING (AP) -- A professor killed the Communist Party secretary at the school of mathematics at China's prestigious Fudan University, police and school authorities said.Police identified the suspect in custody as a 39-year-old professor whose surname is Jiang, saying he used a knife in committing the crime on the school campus.
Human Horizons
May 14, 2021
www.prnewswire.com:443
/PRNewswire/ -- Human Horizons hat heute bekannt gegeben, dass Yifan Li (Frank Li) dem Unternehmen als Chief Financial Officer beigetreten ist. Herr Li wird...
Chen, X., Qi, Y., Wu, Z., Wang, X., Li, J., Zhao, D., Hou, H., Li, Y., Yu, Z., Liu, W., Wang, M., Ren, Y., Li, Z., Yang, H., Xu, Y.
April 30, 2021
Science
Eukaryotic transcription initiation by RNA polymerase II (Pol II) requires the assembly of a preinitiation complex (PIC) on core promoters. The binding of TATA box-binding protein (TBP) to the TATA box promoter has been thought to be a general rule in PIC assembly and transcription initiation. However, most coding genes lack a TATA box, and nearly all Pol II-mediated gene transcription requires the TBP-containing multisubunit complex transcription factor IID (TFIID). Chen et al. determined the structures of human TFIID-based PIC in sequential assembly states and revealed that TFIID supports distinct PIC assembly on TATA-containing and TATA-lacking promoters. The finding resolves the long-standing mystery of how one set of general transcription machinery initiates transcription on diverse promoters. Science , this issue p. [eaba8490][1] ### INTRODUCTION RNA polymerase II (Pol II)-mediated transcription initiation requires assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID (TFIID) recognizes core promoters and recruits TFIIA, TFIIB, TFIIE, TFIIF, TFIIH, and Pol II to sequentially assemble core PIC (cPIC), intermediate PIC (mPIC), and holo PIC (hPIC). The textbook model of transcription initiation starts with binding of TBP (TATA box-binding protein, a TFIID subunit) to TATA box. However, up to 85% of coding genes lack consensus TATA box, and the TFIID complex is required for almost all Pol II-mediated gene transcription. Despite extensive structural studies of TBP-based PIC on TATA box promoters, it remains elusive how TFIID supports PIC assembly on different promoters. ### RATIONALE We reconstituted and determined cryo-electron microcopy structures of the human TFIID-based PIC. Stepwise PIC assembly was characterized by 25 complex structures in different compositional and conformational states on 13 different (natural, composite, and mutant) promoters. Structures of Pol II, TFIID modules, and TBP-promoter at near-atomic resolution permit detailed structural analyses. ### RESULTS Structures in distinct conformations reveal a shared TFIID-binding pattern and loading of TBP to TATA and TATA-less promoters. Unexpectedly, TBP similarly bends TATA box and TATA-less promoters in PIC. PIC assembly on different promoters diverges into two tracks at cPIC and converges at hPIC. On track I, cPIC, mPIC, and hPIC on TATA-DBE promoters adopt the Park, Neutral, and Drive conformations, respectively, indicating stepwise promoter deposition to Pol II accompanied by extensive modular reorganization. On track II, cPIC, mPIC, and hPIC on TATA-only and TATA-less promoters adopt the Drive conformation, indicating direct promoter deposition. The differences result from distinct promoter compositions, which lead to "matched" versus "repositioned" modular separation on promoters and result in distinct PIC architectures and promoter trajectories. In hPIC, TFIID stabilizes PIC organization and supports loading of cyclin-dependent kinase 7 (CDK7) onto Pol II and CDK7-mediated C-terminal domain (CTD) phosphorylation. ### CONCLUSION Our study resolves the long-standing controversy between the lack of TATA box in most core promoters and the necessity of the TFIID complex (but not TBP alone) in transcription. TFIID recognizes promoters and supports TBP-induced promoter bending and two-track PIC assembly on highly diversified core promoters. The stepwise promoter deposition may serve as a checkpoint to prevent promiscuous initiation before PIC is fully assembled, and the hPIC offers a shared starting point for transcription initiation independent of promoter type. Structural visualization of PIC assembly provides a framework for further studies of transcription initiation in the context of transcription factors, coactivators, and epigenetic regulators. ![Figure][2] Schematic model of PIC assembly. Proposed working model of TFIID-supported promoter recognition (inner section) and two-track PIC assembly on different promoters (outer section). P, N, and D denote the Park, Neutral, and Drive conformations, respectively. Right panels (with dashed outlines): Comparison of promoter conformations in cPIC (red), mPIC (yellow), and hPIC (green). Lower panel: The matched and repositioned modular separation on promoters during cPIC assembly. Structures are derived from this study, and representative core promoters are indicated. HMG, high-mobility group; DBE, TFIID-binding element; CAK, CDK-activating kinase. Transcription factor IID (TFIID) recognizes core promoters and supports preinitiation complex (PIC) assembly for RNA polymerase II (Pol II)-mediated eukaryotic transcription. We determined the structures of human TFIID-based PIC in three stepwise assembly states and revealed two-track PIC assembly: stepwise promoter deposition to Pol II and extensive modular reorganization on track I (on TATA-TFIID-binding element promoters) versus direct promoter deposition on track II (on TATA-only and TATA-less promoters). The two tracks converge at an ~50-subunit holo PIC in identical conformation, whereby TFIID stabilizes PIC organization and supports loading of cyclin-dependent kinase (CDK)-activating kinase (CAK) onto Pol II and CAK-mediated phosphorylation of the Pol II carboxyl-terminal domain. Unexpectedly, TBP of TFIID similarly bends TATA box and TATA-less promoters in PIC. Our study provides structural visualization of stepwise PIC assembly on highly diversified promoters. [1]: /lookup/doi/10.1126/science.aba8490 [2]: pending:yes
School of Management, Fudan University
February 24, 2021
www.prnewswire.com:443
/PRNewswire/ -- On the 30th anniversary of the introduction of MBA education into China, Fudan University's MBA program has once again made remarkable...
Ian Sample
December 15, 2020
the Guardian
Sarah Gilbert, professor of vaccinology, led a team of scientists at Oxford University. Photograph: John Cairns/University of Oxford/PA
Ian Sample
December 15, 2020
the Guardian
Sarah Gilbert, professor of vaccinology, led a team of scientists at Oxford University. Photograph: John Cairns/University of Oxford/PA
Singlera Genomics
December 15, 2020
www.prnewswire.com:443
/PRNewswire/ -- Singlera Genomics Inc. today announced that it raised $150 million in Series B financing. This round of financing was led by the CICC Kai Tak...
FinSMEs
November 18, 2020
FinSMEs
About | Advertise | Contact | Disclaimer | News | The Daily Deal Newsletter FinSMEs.com by FinSMEs is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
November 17, 2020
BioSpace
D3 Bio Launches with US$200 Million Investment to Develop Precision Medicines Addressing Unmet Patient Needs in Oncology & Immunology - read this article along with other careers information, tips and advice on BioSpace
Tencent
November 8, 2020
www.prnewswire.com:443
/PRNewswire/ -- The Tencent Medical Enlightenment Summit is online today with the theme of "'The Pain." It has brought together top medical leaders and...
BioSpace
May 15, 2020
BioSpace
Arctic Vision, a clinical stage biotechnology company focusing on the development and commercialization of innovative ophthalmology therapies in China and Asia, announced the formation of its Scientific Advisory Board comprised of three world-class ophthalmologists from China, the United States and the United Kingdom.
March 19, 2020
WebWire
Huawei and Fudan University are working together to deploy an all-optical smart campus network for one of the university's dormitory areas using the Huawei Campus OptiX solution. The network will provide a high-speed Internet access experience for faculty and students, and open up opportunities for implementing innovative teaching methods. To achieve the strategic goal of building a world-class university, Fudan University has set up a three-year action plan for an Internet+ smart cam...

References

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