In Year 198 of the Solar Era in Tokyo, Special Fire Force's are fighting against a phenomenon called Spontaneous Human Combustion where humans beings are turned into living infernos called “Infernals.” While the Infernals are First Generation cases of spontaneous human combustion, later generations possess the ability to manipulate flames while retaining human form.
Shinra Kusakabe is a third generation pyrokinetic youth who gained the nickname "Devil's Footprints" for his ability to ignite his feet at will, and was ostracized as a child for the fire that killed his mother and younger brother Sho twelve years ago. He joins Special Fire Force Company 8, which features other pyrokinetics who dedicated themselves to ending the Infernal attacks for good while investigating Companies 1 through 7 for potential corruption in their ranks. Shinra begins to learn that the fire that killed his mother was a cover for Sho to be taken by the White Clad, a doomsday cult behind the Infernal attacks with agents within the facets of the Tokyo Empire. Company 8 and their allies oppose the White Clad while learning of their goal to gather eight individuals like Shinra and Sho to repeat the Great Cataclysm for an ancient being who manipulated humanity for that very purpose.