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Evaluation of Factors Affecting the Tear-film Lipid Layer Thickness

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clinicaltrials.gov/study/NCT02645045
Is a
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Clinical study
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Clinical Study attributes

NCT Number
NCT026450450
Health Conditions in Trial
Dry eye syndrome
Dry eye syndrome
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Trial Recruitment Size
3500
Trial Sponsor
Yonsei University
Yonsei University
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Clinical Trial Start Date
December 11, 2015
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Primary Completion Date
February 10, 2016
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Study Completion Date
February 10, 2016
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Clinical Trial Study Type
Observational0
Observational Clinical Trial Type
Case-Crossover0
Observational Study Perspective
Cross-Sectional0
Last Updated
January 25, 2017
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Study summary

In this study, the investigators aim to determine the effects of age, sex, history of ocular surgery and contact lens use, and ocular surface and meibomian gland parameters on the lipid layer thickness (LLT) in normal subjects and patients with dry eye syndrome. Patients with dry eye syndrome and subjects with a healthy ocular surface will be enrolled. All participant will underwent LLT measurement with a LipiView interferometer, tear meniscus height measurement using optical coherence tomography, tear film break-up time (TBUT) determination, corneal and conjunctival staining, Schirmer's test, examination of the lid margins and meibomian glands, and assessment using the Ocular Surface Disease Index(OSDI) questionnaire.

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