Is a
Clinical Study attributes
NCT Number
Trial Recruitment Size
1670
Trial Sponsor
Clinical Trial Start Date
February 1, 2016
0Primary Completion Date
October 30, 2018
0Study Completion Date
November 30, 2018
0Clinical Trial Study Type
Observational0
Intervention Type
Other0
Intervention Name
Observation0
Observational Clinical Trial Type
Case-Control0
Observational Study Perspective
Cross-Sectional0
Participating Facility
Official Name
Analysis of Circulating Progenitor Cells Levels in Periodontal Disease Patients0
Last Updated
October 29, 2019
0Study summary
Recently, a key role played in the ethiology of periodontitis has been highlighted by a subtype of stem cells derived from bone marrow, the circulating endothelial progenitor cells (EPCs). EPCs possess the ability to express surface antigens of endothelial and hematopoietic stem cells and to assist in maintaining vascular integrity and the repair mechanism of the endothelium. Among the main markers for the analysis of EPCs levels are CD34+, CD133+ and the kinase insert domain-containing receptor (KDR). CD34+ and CD133+ originate from hematopoietic stem cell antigens whereas KDR is a specific marker of endothelial cells. More specifically, CD34+ and CD133+/ KDR+ allows less mature and mature EPCs to be evaluated.
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