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Cannabinoids and Biological Reactivity to Stress

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Contents

clinicaltrials.gov/study/NCT06430580
Is a
‌
Clinical study
1

Clinical Study attributes

NCT Number
NCT064305801
Health Conditions in Trial
Cannabis use disorder
Cannabis use disorder
1
Trial Recruitment Size
361
Trial Sponsor
Auburn University
Auburn University
1
Trial Collaborator
Wayne State University
Wayne State University
1
Clinical Trial Start Date
August 15, 2024
1
Primary Completion Date
March 15, 2026
1
Study Completion Date
March 15, 2026
1
Clinical Trial Study Type
Interventional1
Interventional Trial Purpose
Basic Science1
Intervention Type
Drug1
Interventional Trial Phase
Early Phase 11
Official Name
Cannabinoids and Biological Reactivity to Stress1
Last Updated
May 28, 2024
1
Allocation Type
Randomized1
Intervention Model
Crossover Assignment1
Masking Type
Triple1
Masked Party
Investigator1
Outcomes Assessor1
Participant1

Other attributes

Intervention Treatment
Cornstarch Placebo 20mg1
Yohimbine Hydrochloride1
Hydrocortisone Oral1
Cornstarch Placebo 54mg1
Study summary

The goal of this study is to test the impact of two drugs that produce temporary stress-like symptoms, both in isolation and together, on cannabis use motivation in individuals with Cannabis Use Disorder. The main questions it will answer are: 1. How do different forms of stress affect cannabis use motivation? 2. How do different forms of stress affect the body's natural cannabinoids? Researchers will compare a placebo to both drugs in isolation, as well as together, across four separate lab visits. Participants will: 1) Complete a clinical screening interview (by phone or in-person) and visit the lab for a medical screening, and if eligible: a) Visit the lab four times where they will: i). Take one of four drug combinations ii). Complete an interview, questionnaires, and computerized tasks iii). Have their brain activity recorded with an EEG cap iv). Provide three blood samples

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