CRISPR-Cas13c

Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR associated (Cas) proteins perform adaptive immune functions in prokaryotic organisms defending against foreign nucleic acids such as viruses. CRISPR/Cas tools have been adapted for use in genome editing and other DNA and RNA targeting applications.

A cluster of topics related to biotechnology.

A cluster of topics related to synthetic biology.

A nucleic acid editing technology that targets RNA, analogous to the CRISPR-Cas9 system

The CRISPR-Cas13a, like other CRISPR-Cas systems functions in bacterial immunity but this system targets invading RNA rather than DNA. CRISPR-Cas13a is being engineered for RNA sensing applications such as live cell RNA tracking and detection of pathogenic viruses or bacteria.

Nucleic acid editing technology that targets RNA and is being developed as a tool for editing pathogenic mutations in RNA transcripts.

CRISPR-Cas13d is a type VI CRISPR-Cas system with the RNA-guided RNase effector Cas13d. CRISPR-Cas13d has potential applications in RNA detection, manipulation and therapeutics. The small size of Cas13d is an advantage for packaging and delivery into cells.