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CRISPR-Cas13

CRISPR-Cas13

A nucleic acid editing technology that targets RNA, analogous to the CRISPR-Cas9 system

CRISPR-Cas13 is an RNA targeting and editing system based on the bacterial immune system that protects them from viruses. Cas13, previously known as C2c2, is the effector protein that targets and cleaves invading nucleic acids from viruses in type VI CRISPR-Cas systems. The CRISPR-Cas13 system is analogous to the CRISPR-Cas9 system. However, unlike Cas-9 which targets DNA, Cas-13 targets and cleaves single stranded RNA. Cas-13 was first discovered in L. shahii, a species of the Leptotrichia bacteria while researchers were looking for previously unidentified CRISPR systems. Members of Cas13, Cas13a and Cas13b are being developed for therapeutic gene correction at the RNA level and detection of viral pathogens.

Timeline

Key paper released

Paper published on in vivo RNA targeting

People

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Role
Related Golden topics

Eugene Koonin

Primary Investigator

Feng Zhang

Primary Investigator

Pardis C. Sabeti

Primary Investigator

Further reading

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C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

Abudayyeh et al.

Academic paper

CRISPR/Cas13 as a Tool for RNA Interference

Zahir Ali

Academic paper

New Version of CRISPR, Developed by Feng Zhang–Led Team, Can Target and Edit RNA

Alex Philippidis

Academic paper

RNA editing with CRISPR-Cas13

David B. T. Cox

Academic paper

Documentaries, videos and podcasts

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Companies

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References