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Will Douglas Heaven
April 8, 2021
MIT Technology Review
Slick, viral videos from Boston Dynamics are impressive but teaching a robot to walk by itself is a lot harder.
Abdella, R., Talyzina, A., Chen, S., Inouye, C. J., Tjian, R., He, Y.
April 2, 2021
Science
The Mediator complex is recruited by transcription factors to all protein-coding genes in eukaryotes and helps to assemble the machinery necessary to transcribe the gene. Abdella et al. present the cryo-electron microscopy structure of the human Mediator-bound preinitiation complex (Med-PIC). The structure shows how Mediator positions the long, flexible C-terminal domain of RNA polymerase II to be phosphorylated by the kinase CDK7, a crucial step for further processing of the RNA into a mature RNA. Most sites where transcription factors bind to Mediator are flexibly tethered to the complex, allowing the large Med-PIC to assemble at any gene. Science , this issue p. [52][1] Eukaryotic transcription requires the assembly of a multisubunit preinitiation complex (PIC) composed of RNA polymerase II (Pol II) and the general transcription factors. The coactivator Mediator is recruited by transcription factors, facilitates the assembly of the PIC, and stimulates phosphorylation of the Pol II C-terminal domain (CTD) by the TFIIH subunit CDK7. Here, we present the cryo-electron microscopy structure of the human Mediator-bound PIC at a resolution below 4 angstroms. Transcription factor binding sites within Mediator are primarily flexibly tethered to the tail module. CDK7 is stabilized by multiple contacts with Mediator. Two binding sites exist for the Pol II CTD, one between the head and middle modules of Mediator and the other in the active site of CDK7, providing structural evidence for Pol II CTD phosphorylation within the Mediator-bound PIC. [1]: /lookup/doi/10.1126/science.abg3074
Lila Thulin
March 9, 2021
Smithsonian Magazine
A new book from Steve Jobs biographer Walter Isaacson offers an incisive portrait of the gene editing field that is changing modern medicine
Veggie Grill
March 10, 2021
www.prnewswire.com:443
/PRNewswire/ -- It's time to eat like you give a shake and stand up for change. Created by the team at Veggie Grill, Stand-Up Burgers, the 100 percent...
University of Chicago
February 26, 2021
www.prnewswire.com:443
/PRNewswire/ -- The University of Chicago's Board of Trustees has named Paul Alivisatos as the University's 14th president. An accomplished leader in higher...
Elizabeth Landau
February 21, 2021
Wired
By digging out signals hidden within the brain's electrical chatter, scientists are getting new insights into sleep, aging, and more.
New Age Meats
February 10, 2021
www.prnewswire.com:443
/PRNewswire/ -- New Age Meats ("NAM"), a cultivated and plant-based meat startup in Berkeley, CA with an initial focus on pork, announces an additional $2M in...
Laurence Dodds
January 20, 2021
The Telegraph
Joe Biden's vice presidential nomination made her name by carefully weaving between moderate Democrats and radical socialists
Laurence Dodds
January 19, 2021
The Telegraph
Joe Biden's vice presidential nomination made her name by carefully weaving between moderate Democrats and radical socialists
Dennis Overbye
December 31, 2020
www.nytimes.com
A spooky radio signal showed up after a radio telescope was aimed at the next star over from our sun.
Matthew A. Brown
December 15, 2020
Scientific American
Scientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our understanding of the world and shape our lives.
Science X staff
December 15, 2020
phys.org
Researchers from Bochum and Berkeley have investigated why cages can increase the catalytic activity of enclosed molecules. Using terahertz spectroscopy and complex computer simulations, they showed that water encapsulated in a tiny cage has special properties--that are structurally and dynamically distinct from any known phase of water. The water forms a droplet inside the cage that facilitates the encapsulation of a host molecule, i.e. to access the catalytic center. The research team describes the thermodynamic properties of this special form of water, which have never been observed before, in the journal Proceedings of the National Academy of Sciences (PNAS) published online on 14 December 2020.
Natalie Wolchover
December 8, 2020
Nautilus
Reprinted with permission from Quanta Magazine's Abstractions blog.A team in Paris has made the most precise measurement yet of...
Stephen Pritchard
December 4, 2020
ComputerWeekly.com
We look at RAID and flash to highlight key choices when it comes to drive data protection. What RAID levels work best with solid state and when is erasure coding a good choice?
Joanna Glasner
November 27, 2020
Crunchbase News
The incoming administration's level of connection to the tech and VC sphere varies considerably among key government role appointees.
BioSpace
November 16, 2020
BioSpace
In an unprecedented collaboration designed to speed research advances, Duchenne UK, the Muscular Dystrophy Association (MDA) and Parent Project Muscular Dystrophy (PPMD) have announced a joint grant of $686,500 to Dr. William Evans (principal investigators
Libertina Brandt
November 13, 2020
Business Insider
America is less than 300 years old. But many homes in some historic metropolitan areas date back to the country's colonial era.
Laurence Dodds
November 10, 2020
The Telegraph
Joe Biden's vice president nomination made her name by carefully weaving between moderate Democrats and radical socialists
Laurence Dodds
November 9, 2020
The Telegraph
Joe Biden's vice president nomination made her name by carefully weaving between moderate Democrats and radical socialists
November 8, 2020
Hindustan Times
During his North Carolina political rally, President Donald Trump targeted Kamala Harris, saying, "She could never be the first woman vice president. . . That would be an insult to our country." Now, Kamala Harris is the vice president-elect of the United States of America.
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