Antibody-like Scaffold Protein

Scaffold proteins are characterized by the ability to simultaneously interact and/or bind with multiple other proteins, and organize partner proteins into a framework to facilitate their concerted interactions and functions. In biology realm, scaffold proteins play a crucial role in a wide range of biotechnological and pharmaceutical applications. They can be treated as a kind of antibody mimetics in the development or application of therapeutic and diagnostic tools.

Types of scaffold proteins, including over 30 different types, such as 10-FnIII, Affilin, Min-23, Ubiquitin, Kunitz domains, PDZ domain, Z-domain of protein A etc.