Clinical Studies Sponsored by Akebia Therapeutics | 30 results

Trial Evaluating the Efficacy and Safety of Oral Vadadustat Once Daily (QD) and Three Times Weekly (TIW) for the Maintenance Treatment of Anemia in Hemodialysis Subjects Converting From Erythropoiesis-Stimulating Agents (ESAs)

Name	NCT Number	Health Conditions in Trial	Clinical Trial Start Date	Study Completion Date	Clinical Trial Study Type
‌ Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)	NCT02680574	Anemia	2016	July 31, 2020	Interventional
‌ Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease	NCT02648347	Anemia	2015	July 31, 2020	Interventional
‌ Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Participants With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD)	NCT02865850	Anemia	2016	March 30, 2020	Interventional
‌ Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Non-Dialysis Dependent Chronic Kidney Disease (NDD-CKD)	NCT03054337	Anemia	2016	August 28, 2017	Interventional
‌ Study to Evaluate Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) Who Are Hyporesponsive to Erythropoiesis Stimulating Agents	NCT03140722	Anemia	May 2, 2017	March 21, 2018	Interventional
‌ Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin	NCT03801733		June 17, 2018	November 24, 2018	Interventional
‌ Relative Bioavailability of Two Formulations of AKB-6548 and the Food Effect of a New Tablet in Healthy Adult Subjects	NCT02412449	‌ Healthy	2015	2015	Interventional
‌ Effect of AKB-6548 on the Pharmacokinetics of Celecoxib	NCT02502500		2015	2015	Interventional
‌ Study to Evaluate Three Times Per Week (TIW) Oral Dosing of Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD)	NCT03242967	Anemia	2017	February 12, 2018	Interventional
‌ Effect of AKB-6548 on Cardiac Repolarization Intervals in Healthy Volunteers	NCT02062203		2014	2014	Interventional
‌ A Study in Evaluating Bioequivalence of Test and Reference Vadadustat 450 MG and 150 MG Tablets and to Determine Food Effect on the 450 MG Tablet	NCT03657290	‌ Healthy	August 3, 2018	October 16, 2018	Interventional
‌ 16-Week Repeat Oral Dose Study of AKB-6548 for Anemia in Participants With End Stage Renal Disease (ESRD) Requiring Chronic Hemodialysis	NCT02260193	Anemia	September 10, 2014	July 22, 2015	Interventional
‌ A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (HFpEF)	NCT03254485	‌ Heart failure with preserved ejection fraction	November 7, 2017	August 19, 2019	Interventional
‌ A Study to Evaluate the Soluble Guanylate Cyclase (sGC) Stimulator IW-1973 in Diabetic Nephropathy / Diabetic Kidney Disease as Measured by Albuminuria	NCT03217591		August 1, 2017	August 20, 2019	Interventional
‌ Safety and Efficacy Study for AKB-6548 in Participants With Chronic Kidney Disease and Anemia	NCT01235936	Anemia ‌ Kidney disease	October 21, 2010	2011	Interventional
‌ Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Dialysis-dependent Chronic Kidney Disease (DD-CKD)	NCT02892149	Anemia	2016	March 30, 2020	Interventional
‌ Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease	NCT05082571		2025	2026	Interventional
‌ Study to Assess the Safety and Pharmacokinetics of AKB-6548 in Participants With Chronic Kidney Disease (CKD), Stages 3 and 4	NCT04707573	Chronic kidney disease	July 8, 2010	September 24, 2010	Interventional
‌ 42-Day Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia	NCT01381094	Anemia ‌ Kidney disease	June 15, 2011	February 16, 2012	Interventional
‌ Study of Vadadustat in Hemodialysis Participants With Anemia Switching From Epoetin Alfa	NCT03799627	Anemia	January 31, 2019	July 15, 2020	Interventional
‌ Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin	NCT03801746		July 20, 2018	August 15, 2018	Interventional
‌ Study in Healthy Adult Subjects to Assess the Effect of Phosphate Binders on the Pharmacokinetics of a Single Dose of Vadadustat	NCT04299633		June 15, 2020	September 28, 2020	Interventional
‌ Trial Evaluating the Efficacy and Safety of Oral Vadadustat Once Daily (QD) and Three Times Weekly (TIW) for the Maintenance Treatment of Anemia in Hemodialysis Subjects Converting From Erythropoiesis-Stimulating Agents (ESAs)	NCT04313153	Anemia	May 27, 2020	June 22, 2022	Interventional
‌ Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Vadadustat in Hemodialysis Subjects With Anemia Associated With Chronic Kidney Disease	NCT03992066		May 28, 2019	July 15, 2020	Interventional
‌ Effects of Ferrous Sulfate on the Pharmacokinetics of AKB-6548	NCT02327546		2014	2015	Interventional