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US Patent 9944919 Tethering cysteine residues using cyclic disulfides

Patent 9944919 was granted and assigned to Brandeis University on April, 2018 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

Brandeis University

1

Current Assignee

Brandeis University

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Jeffrey N. Agar1

Joseph Salisbury1

Date of Patent

April 17, 2018

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Patent Application Number

152198071

Date Filed

July 26, 2016

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Patent Citations Received

US Patent 11987827 Tethering cysteine residues using cyclic disulfides

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Patent Primary Examiner

Iqbal H Chowdhury

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Patent abstract

Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.

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